A different Louisville team emerged in the second half after being down by 8 after the first 20 minutes of play. The cardinals outscored the Wildcats by 22 as Louisville won 69-55 in the Semifinals of the Big East Tournament.
The Wildcats had difficulties in the second half with the Cards' full court pressure.
Dante Cunningham and corey Fisher each had 14. Dwayne Anderson added 12 for Villanova who finishes the regular season and conference play 26-7.
'Nova now waits until Sunday evening to see who they will face in the NCAA Tournament.