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Villanova, who enters the 2015 Football season at #4 in the media poll and #3 in the coaches, will kick off their season on Thursday night against the Connecticut Huskies. However, they aren't the only FCS team taking on an FBS this weekend.
With the opportunity to start an FCS team's season off on the right foot, and summarily ruining an FBS's season, here are the David vs. Goliath matchups occurring on the first weekend of College Football.
All times Eastern Standard Time.
Thursday September 3rd
VMI at Ball State, 7p [ESPN3]
Stony Brook at Toledo, 7p [ESPN3]
Elon at Wake Forest, 7p [ESPN3]
#4 Villanova at Connecticut, 7:30p [ESPN3]
Alcorn State at Georgia Tech, 7:30p [ESPN3]
Southern Utah at Utah State, 9p
Abilene Christian at Fresno State, 10p
UC Davis at Nevada, 10p
#9 New Hampshire at San Jose State, 10p
Friday, September 4th
#20 Fordham at Army West Point, 7p
Rhode Island at Syracuse, 7p [ESPN3]
Weber State at Oregon State, 8p [Pac12]
Saturday, September 5th
#2 Illinois State at Iowa, noon [BTN]
#16 South Dakota State at Kansas, noon
#18 Richmond at Maryland, noon [ESPNU]
Colgate at Navy, noon [CBSSN]
UT Martin at Ole Miss, noon [SEC Network]
Norfolk State at Rutgers, noon [ESPNEWS]
Wofford at Clemson, 12:30p [ESPN3]
Maine at Boston College, 1p [ESPN3]
#14 Youngstown State at Pittsburgh, 1p [ESPN3]
Portland State at Washington State, 2p [PAC12]
Morgan State at Air Force, 3:30p
Howard at Appalachian State, 3:30p [ESPN3]
Albany at Buffalo, 3:30p [ESPN3]
Presbyterian at Miami (OH), 3:30p [ESPN3]
Wagner at Rice, 3:30p
#3 Sam Houston State at Texas Tech, 3:30p
Savannah State at Colorado State, 4p
Southern Illinois at Indiana, 4p [ESPNEWS]
Southeast Missouri at Missouri, 4p [SEC Network]
North Dakota at Wyoming, 4p
Grambling State at California, 5p [PAC12]
Towson at East Carolina, 6p [ESPN3]
Bethune-Cookman at Miami (Fla.), 6p [ESPN3]
Gardner-Webb at South Alabama, 6p [ESPN3]
Alabama A&M at Cincinnati, 7p [ESPN3]
Southern at Louisiana Tech, 7p
Missouri State at Memphis, 7p [ESPN3]
Jackson State at Middle Tennessee State, 7p
Florida A&M at South Florida, 7p [ESPN3]
South Dakota at Kansas State, 7:10p
#25 McNeese State at LSU, 7:30p [SEC Network]
Tennessee Tech at Houston, 8p [ESPN3]
#10 Northern Iowa at Iowa State, 8p
Mississippi Valley State at New Mexico, 8p
#6 Eastern Washington at Oregon, 8p [PAC12]
San Diego at San Diego State, 8p